Correlation Between Hepatitis B G1896A Precore Mutations and HBeAg in Chronic HBV Patients

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Correlation Between Hepatitis B G1896A Precore Mutations and HBeAg in Chronic HBV Patients

BACKGROUND Hepatitis B virus (HBV) infection is an important health concern worldwide, with critical outcomes. Hepatitis B e antigen (HBeAg) negative chronic hepatitis B is frequently caused by a mutation (G1896A) in the hepatitis B virus (HBV) precore (PC) reading frame, which creates a stop codon, causing premature termination of the HBe protein. OBJECTIVES This study aimed to investigate t...

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correlation between hepatitis b g1896a precore mutations and hbeag in chronic hbv patients

conclusions this study indicates that the rate of g1896a mutation at the pc region among hbeag negative patients, in the golestan province of iran, was similar to the average rate encountered in other parts of iran. the pc stop codon mutation was detected in 93.18% of hbeag negative patients. further studies with larger sample sizes are required to elucidate the exact role of these mutations in...

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correlation between viral load of hbv in chronic hepatitis b patients and precore and basal core promoter mutations

background more than two billion people have been exposed to hepatitis b virus (hbv) worldwide. furthermore, four hundred million of them are infected with chronic hbv infection. the predominant mutation of the precore region involves a g to a change at nucleotide1896, which creates a premature stop codon at codon 28. two mutations of a1762t and g1764a are reported as the most prevalent mutatio...

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Correlation Between Viral Load of HBV in Chronic Hepatitis B Patients and Precore and Basal Core Promoter Mutations

BACKGROUND More than two billion people have been exposed to hepatitis B virus (HBV) worldwide. Furthermore, four hundred million of them are infected with chronic HBV infection. The predominant mutation of the precore region involves a G to A change at nucleotide1896, which creates a premature stop codon at codon 28. Two mutations of A1762T and G1764A are reported as the most prevalent mutatio...

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G1896A Precore Mutation and Association With HBeAg Status, Genotype and Clinical Status in Patients With Chronic Hepatitis B

BACKGROUND Precore stop codon (G1896A) mutation is one of the commonest mutations found in patients with chronic hepatitis B. However, over the years, this mutation was not reported much in Malaysia. OBJECTIVES We therefore investigated the presence of G1896A mutation in Malaysian population and its association with HBeAg status, clinical stage, hepatitis B virus (HBV) genotype and e-seroconv...

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ژورنال

عنوان ژورنال: Jundishapur Journal of Microbiology

سال: 2015

ISSN: 2008-3645,2008-4161

DOI: 10.5812/jjm.17126